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  • Picrosirius
  • Tendon Cell Lineage
  • 3D Reconstruction: Tendon, Bone, Scar

Musculoskeletal and Soft Tissue Fibrosis and Regeneration Lab

The overarching goals of our research program are to: i) identify novel strategies to promote regenerative tendon healing; ii) develop strategies to preserve tendon structure-function through the lifespan; and iii) understand the cellular and molecular drivers of soft tissue fibrosis, with a particular emphasis on the musculoskeletal system.

Loiselle Lab Team

Alayna E. Loiselle, Ph.D.

Alayna E. Loiselle, Ph.D.
Principal Investigator

Lab Members
Research Projects
Working in the Lab
News

Projects

Myofibroblast

Tendon Regeneration

Tendon Cell Aging

Maintain Tendon Structure-Function Through the Lifespan

Adhesion

Mechanisms of Soft Tissue Fibrosis

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Publications

Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function. Ackerman JE, Best KT, Muscat SN, Pritchett EM, Nichols AEC, Wu C, Loiselle AE. Cell Reports. 2022 Nov 22. 41(8).

Best KT, Korcari A, Mora KE, Nichols AE, Muscat SN, Knapp E, Buckley MR, Loiselle AE. Elife. 2021 Jan 22;10:e62203. doi: 10.7554/eLife.62203. PMID: 33480357.

Best KT, Nichols AEC, Knapp E, Hammert WC, Ketonis C, Jonason JH, Awad HA, Loiselle AE. Sci Signal. 2020 Nov 17;13(658):eabb7209. doi: 10.1126/scisignal.abb7209. PMID: 33203721.

Ackerman JE, Nichols AE, Studentsova V, Best KT, Knapp E, Loiselle AE. Elife. 2019 May 24;8:e45342. doi: 10.7554/eLife.45342. PMID: 31124787.

Affiliations

Center for Musculoskeletal Research

Orthopaedics

Pathology & Laboratory Medicine

Cell Biology of Disease PhD Program

Biomedical Genetics & Genomics PhD Program

News

February 11, 2022
Â鶹ÊÓƵResearchers Reflect on International Day of Women and Girls in Science

January 31, 2022
2022 Kappa Delta Young Investigator Award Presented to Alayna E. Loiselle, PhD

July 28, 2021
$2M Grant Supports CMSR Study of Biologic Factors in Tendon Healing

March 1, 2020
Strong CMSR Representation at the 2020 ORS Meeting

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Contact Us

  Loiselle Lab
MC 1-8834
601 Elmwood Ave
Rochester, NY 14642

  (585) 275-7239

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